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Nature, Published online: 26 February 2026; doi:10.1038/d41586-026-00158-y

ME – also known as Chronic Fatigue Syndrome – has long been one of medicine’s most perplexing conditions. With no definitive diagnostic test and a legacy of scepticism in parts of the medical community, patients have often struggled to be believed. But a surge of new research may finally be shifting the landscape.

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